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Nicotinamide mononucleotide is a naturally occurring molecule that chemically belongs to the group of biologically active nucleotides. It is the precursor to nicotinamide adenine dinucleotide (NAD+), which is the driving force behind the body's production of NAD+, an important coenzyme involved in a variety of biological processes including aging and gene expression. “NAD+ is involved in the process of converting the food we eat into energy for our cells,” explains Kathryn Piper, a registered licensed dietitian in Missouri and Illinois. “It also helps enzymes in the body to repair DNA and prevent damage to our cells.”

Naturally occurring 

Beta-nicotinamide mononucleotide is found in a variety of natural foods, including broccoli, cabbage, cucumber skin and cucumber seeds. Recent studies have shown that it is absorbed very quickly. Studies have found that supplementation with beta-nicotinamide mononucleotide has a number of beneficial effects on the body, including skeletal muscle, liver function, and bone density. However, these benefits were only evident in older mice, and had no significant effect on younger mice. This may be due to the fact that younger mice are able to produce sufficient amounts of beta-nicotinamide mononucleotide on their own, and the increased inflammation that occurs along with aging weakens the body's ability to produce it, which in turn causes a decrease.

The efficacy of NMN

1, NMN helps to slow down aging

NAD + (coenzyme I) to maintain chemical communication between the nucleus and mitochondria, if this communication is weakened, will lead to mitochondrial decline, mitochondrial decline is an important cause of cellular aging, NAD + (coenzyme I) can maintain the normal expression of genes, to maintain the cell's full-time function, slowing down the process of cellular evolution into senescent cells.

2、NMN helps prevent three highs and diabetes

The key to lowering blood sugar is insulin, if the pancreatic islet cells are destroyed to cause insulin secretion disorder, then it is easy to cause diabetes, NMN can stimulate insulin activity, strengthen the decomposition of fats and polysaccharides, so NMN can reduce the risk of diabetes.

3、NMN helps to prevent cardiovascular diseases

Clinical studies on atherosclerosis and related cardiovascular diseases show that oxidation of LDL is an important cause of atherosclerosis. And NMN mainly prevents cardiovascular diseases by: increasing HDL, decreasing LDL, being oxidized, reducing the inflammatory reaction of macrophages, decreasing the formation of atherosclerotic plaque, increasing the stability of atherosclerotic plaque, decreasing the rupture of plaque, and improving the blood flow and other ways mentioned above.

4、NMN helps to enhance immunity

NMN can promote spleen cells to produce antibodies, enhance the role of immune T-cells, stimulate the production of immunoglobulin in the body, and has an important immunomodulatory effect.

5、NMN helps prevent cancer

Experimental results show that NMN has significant anticancer properties, NMN can also induce liver metastatic enzymes, the effect is more obvious than β-carotene, NMN can also prevent the carcinogenicity of aflatoxin, to reduce the number of aflatoxin-induced liver tumors and the volume of cells with good results.

6、NMN helps to prevent high blood pressure

NMN mainly inhibits and reverses atherosclerosis by supplementing NAD, so that the foam cells gradually restore the smooth muscle cells of blood vessels, thus restoring the elasticity of blood vessels, and at the same time prevents the re-formation of thrombus through anti-inflammatory effects, then opens up the blocked collateral circulation and expands the volume of blood, so as to continuously and slowly reduce blood pressure.

7、Maintain the regenerative ability of capillaries

Muscle cells release growth factors during exercise, capillary epidermal cells receive growth factors and accelerate growth, this process depends on NAD + (coenzyme I) generated by the longevity protein Sirtuin1, the older the person, the less NAD + (coenzyme I), the exercise stimulates the effect of muscle growth is also worse.

8, alcohol metabolism

Alcohol metabolism is divided into two steps, first into toxic acetaldehyde, and then further decomposition into harmless acetic acid, each step must rely on the catalytic coenzyme I.

9、NMN helps protect vision

The human retina-like and central nervous system is rich in unsaturated fatty acids. Therefore, free radicals generated by oxidation can easily cause peroxidative damage to them. Research has found that NMN can easily pass through the blood-brain barrier and cell membranes, can effectively prevent retinal oxidation, the central nervous system, especially for the brain to play a protective role, so as to effectively treat spinal cord injury, Parkinson's syndrome, Alzheimer's syndrome and other central nervous system damage. Especially the retinal macular degeneration effect is more significant compared to lutein.

10、Improve sleep

Supplementation of NMN can enhance the body's NAD + level, and NAD + and the biological clock also has a great relationship between the interaction of NAD + and the biological clock: NAD + metabolism is regulated by the biological clock, which in turn also has an impact on the biological clock. For people who do not get enough sleep or have an irregular routine, boosting NAD+ levels in the body can help regulate the biological clock and restore it to its normal circadian rhythm.

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